Dr Chou

The second the kick-off occurs, anything can occur.    —   Dean Chou

     Dean Chou holds a D.Phil. in integrative cerebral biomechanics from the University of Oxford (2011-2017). He focused on the multiscale cerebral poromechanics research where he applied poromechanics theory that forms an integral part of an advanced numerical template that is able to capture the multiscale complexity of the neurovascular unit. Specifically, the goal of his research was to create a cerebral poromechanics model, which adapts to the newly discovered glymphatic system and incorporates with water channels (aquaporins, AQPs) in order to investigate neurological disorders such as Alzheimer's Disease (AD), Cerebral Oedema, Hydrocephalus and Traumatic Brain Injury (TBI). During his D.Phil., he was supported by the Virtual Physiological Human: DementiA Research Enabled by IT (VPH-DARE@IT) project, a project from the seventh Framework Programmes (FP7) for research and technological development created by the European Union/European Commission.

     He received his second MSc. degree from the Department of Chemical and Material Engineering at the University of Alabama in Huntsville (2009-2010), where he was awarded a full scholarship. During this period, he worked on the fluid-structure interaction (FSI) problem regarding DNA folding/stretching mechanics and numerical solver development at the ESI group in Huntsville as well. He completed his first MSc. degree and BSc. degree in the Department of Engineering Science and Ocean Engineering at the National Taiwan University (2002-2005) and the Department of Systems Engineering & Naval Architecture at the National Taiwan Ocean University (1997-2002), respectively. During his first MSc thesis, he studied the nonsingular boundary integral equations (BIEs) and utilised them to solve a variety of internal flow problems.


Specialities

  •     Poromechanics
  •     Transport Phenomena
  •     Computational Fluid Dynamics
  •     Machine Learning
  •     Imaging Processing
  •     Biosensors

Research Achievements

Journal Papers (*, equal contribution)

[08] L.W. Guo, J.C. Vardakis, D. Chou, Y. Ventikos (2020, Feb). A multiple-network poroelastic model for biological systems and application to subject-specific modelling of cerebral fluid transport. International Journal of Engineering Science, (IF: 9.219, 01/91, Engineering, Multidisciplinary).

[07] Vardakis I, Guo L, Peach T, Lassila T, Mitolo M, D. Chou, Taylor Z, Varma S, Venneri A, Frangi A, Ventikos Y (2019, Nov). Fluid–structure interaction for highly complex, statistically defined, biological media: Homogenisation and a 3D multi-compartmental poroelastic model for brain biomechanics. Journal of Fluids and Structures, (IF: 2.840, 22/134, Mechanics).

[06] L.W. Guo, J.C. Vardakis, T. Lassila, M. Mitolo, N. Ravikumar, D. Chou, M. Lange, A. Sarrami-Foroushani, B.J. Tully, Z.A. Taylor, S. Varma, A. Venneri, A.F. Frangi, Y. Ventikos (2018, Feb). Subject-specific multiporoelastic model for exploring the risk factors associated with the early stages of Alzheimers disease. Interface Focus, 6; 8(1): 20170019, (IF: 3.514, 21/93, Biology).

[05] P. H. Tsui, J. Fang, K. J. Chang, W. H. Kuo, H. Y. Ma and D. Chou (2017, Jan). Small-window parametric imaging based on information entropy for ultrasound tissue characterization. Scientific Reports, 7, Article No: 41004. (IF: 4.122, 12/64, Multidisciplinary Sciences).

[04] D. Chou, J. C. Vardakis, L. W. Guo, B. J. Tully and Y. Ventikos (2016, Jul). A fully dynamic multicompartmental poroelastic system: application to aqueductal stenosis. Journal of Biomechanics, 49(11), 2306~2312. (IF: 2.664, 25/77, Engineering, Biomedical).

[03] J. C. Vardakis, D. Chou, B. J. Tully, C. C. Hung, T. H. Lee, P. H. Tsui and Y. Ventikos (2016, Jan). Investigating cerebral oedema using poroelasticity. Medical Engineering & Physics, 38(1), 48~57. (IF: 1.819, 46/77, Engineering, Biomedical).

[02] S. B. Huang, D. Chou, Y. H. Chang, K. C. Li, T. K. Chiu, Y. Ventikos and M. H. Wu (2015, Dec). Development of a pneumatically driven active cover lid for multi-well microplates for use in perfusion three-dimensional cell culture. Scientific Reports, 5, Article No: 18352. (IF: 5.228, 07/63, Multidisciplinary Sciences).

[01] D. Chou, J. C. Vardakis and Y. Ventikos, Multiscale modelling for cerebrospinal fluid dynamics: multi-compartmental poroelacticity and the role of AQP4, Journal of Biosciences and Medicines, Volume 2, Pages 1~9, 2014.

Conference Papers

[33] B.Z Lu, D. Chou, K. Hsieh, W.J. Liang, C.Y. Yeh, Y.T. Chun, and Y.C. Shu (2019, Jun). Level Set Method for Image Segmentation. 6th International Conference on Computational and Mathematical Biomedical Engineering.

[32] D. Chou, S.K. Liao, J.C. Vardakis, and Y.C. Shu (2019, Jun). An Analytical Steady-state Solution for Cerebral Tissue based on Multiple-network Poroelasticity. 6th International Conference on Computational and Mathematical Biomedical Engineering, Sendai, Japan.

[31] D. Chou, J.C. Vardakis, Y. Ventikos (2018, Jul). A novel poroelastic model of the neuro-glio-vascular unit. 8th World Congress of Biomechanics, Dublin, Ireland.

[30] J.C. Vardakis, L.W. Guo, T. Lassila, M. Mitolo, N. Ravikumar, D. Chou, M. Lange, A.S. Foroushani, B. Tully, Z. Taylor, S. Varma, A. Venneri, A.F. Frangi, Y. Ventikos (2018, Jul). A personalised multi-poroelastic model for exploring the risk factors associated with the early stages of Alzheimer’s disease. 8th World Congress of Biomechanics, Dublin, Ireland.

[29] L.W. Guo, J.C. Vardakis, D. Chou, B. Tully, Yiannis Ventikos (2018, Jul). Subject-specific computational platform of a multiporoelastic model for the simulation of cerebrospinal fluid transport. 8th World Congress of Biomechanics, Dublin, Ireland.

[28] J.C. Vardakis, L.W. Guo, D. Chou, Y. Ventikos (2018, Jun). Using Multicompartmental Poroelasticity to Explore Brain Biomechanics and Cerebral Diseases. IUTAM Symposium on Critical flow dynamics involving moving/deformable structures with design applications, Santorini, Greece.

[27] J.C. Vardakis, L.W. Guo, D. Chou, Y. Ventikos (2018, Jun). Cerebroventricular Fluid Complexity in the early stages of Alzheimer's Disease. 6th European Conference on Computational Mechanics, 7th European Conference on Computational Fluid Dynamics, Glasgow, UK.

[26] J. C. Vardakis, L. W. Guo, D. Chou, B. Tully, G. F. Vindedal, V. Jensen, A. E. Thoren, K. H. Pettersen, S. W. Omholt, O. P. Ottersen, E. A. Nagelhus and Y. Ventikos, Poroelastic modelling of CSF circulation via the incorporation of experimentally derived microscale water transport properties, 5th International Conference on Computational and Mathematical Biomedical Engineering, At University of Pittsburgh, Pittsburgh, PA, United States, 2017/04.

[25] L. W. Guo, J. C. Vardakis, T. Lassila, M. Mitolo, N. Ravikumar, D. Chou, M. Lange, A. S. Foroushani, B. Tully, Z. Taylor, S. Varma, A. Venneri, A. F. Frangi, Y. Ventikos, Investigating dementia via a multi-compartmental poroelastic model of parenchymal tissue, 5th International Conference on Computational and Mathematical Biomedical Engineering, At University of Pittsburgh, Pittsburgh, PA, United States, 2017/04.

[24] Y. Ventikos, J. C. Vardakis, L. W. Guo, T. Lassila, D. Chou, B. Tully, N. Ravikumar, M. Mitolo, M. Lange, A. S. Foroushani, Z. Taylor, S. Varma, A. Venneri and A. F. Frangi, Mechanistic model-based biomarkers, European Congress of Radiology, At Vienna, Austria, 2017/03.

[23] C. W. Chang, H. Y. Chih, D. Chou, Y. C. Shu and K. T. Chuang, Relief of spatiotemporal accessibility overloading with optimal resource placement, Proc. of the IEEE International Conference on Data Mining (triple-blind review, regular paper, acceptance rate=8.5% out of 923 submissions, 2016/09.

[22] J. C. Vardakis, L. W. Guo, D. Chou, B. Tully, T. Lassila, N. Ravikumar, Z. A. Taylor, S. Varma, A. Venneri, A. F. Frangi and Y. Ventikos, Investigating patient-specific cerebroventricular fluid complexity in dementia, Virtual Physiological Human Conference, Amsterdam, Netherlands, 2016/09.

[21] L. W. Guo, J. C. Vardakis, D. Chou, B. Tully, T. Lassila, N. Ravikumar, Z. A. Taylor, S. Varma, A. Venneri, A. F. Frangi and Y. Ventikos, Patient-specific multiporoelastic brain modelling, Virtual Physiological Human Conference, Amsterdam, Netherlands, 2016/09.

[20] L. W. Guo, J. C. Vardakis, D. Chou and Y. Ventikos, Development of a three-dimensional multi-compartmental poroelastic model for the simulation of cerebrospinal fluid transport, 12th World Congress on Computational Mechanics and 6th Asia-Pacific Congress on Computational Mechanics, Seoul, Korea, 2016/07.

[19] J. C. Vardakis, L. W. Guo, D. Chou and Y. Ventikos, Exploring obstructive hydrocephalus through a multiscale modelling approach, 4th International Conference on Computational and Mathematical Biomedical Engineering, Paris, France, 2016/06.

[18] Y. Ventikos, J. C. Vardakis, D. Chou, L. G. Guo and B. Tully, Fluid transport in the ageing brain: an integrative modelling approach, European Congress of Radiology, At Vienna, Austria, 2016/03.

[17] D. Chou, J. C. Vardakis, L. W. Guo and Y. Ventikos, A Fully dynamic multi-compartmental poroelastic system: application to aqueductal stenosis, First Computational Mechanics Conference in Taiwan, Taipei, Taiwan, 2015/10.

[16] J. C. Vardakis, D. Chou, L. W. Guo and Y. Ventikos, Multi-compartmental poroelasticity for the integrative modelling of periventricular lucency, 4th International Conference on Computational and Mathematical Biomedical Engineering, Paris, France, 2015/07.

[15] J. C. Vardakis, D. Chou, L. W. Guo, B. Tully and Y. Ventikos, Investigating cerebral oedema using poroelasticity, 3rd International CSF Dynamics Symposium, Amiens, France, 2015/07.

[14] J. C. Vardakis, D. Chou, B. J. Tully and Y. Ventikos, Multi-compartmental poroelasticity for the integrative modelling of fluid transport in the brain, 9th European Solid Mechanics Conference, Madrid, Spain, 2015/07.

[13] D. Chou, J. C. Vardakis, B. J. Tully and Y. Ventikos, Understanding hydrocephalus using a multi-compartmental poroelasticity model, 18th International Conference on Finite Elements in Flow Problems (FEF2015), Taipei, Taiwan, 2015/03.

[12] J. C. Vardakis, D. Chou, B. J. Tully and Y. Ventikos, A CFD and FEM approach to a multi-compartmental poroelastic model for CSF production and circulation with applications in hydrocephalus treatment and cerebral oedema, 4th Micro and Nano Flows Conference 2014, London, UK, 2014/09.

[11] J. C. Vardakis, D. Chou, B. J. Tully and Y. Ventikos, Exploring a multi-compartmental poroelastic model for the integrative modelling of fluid transport, 7th World Congress of Biomechanics, Boston, USA, 2014/07.

[10] D. Chou, J. C. Vardakis and Y. Ventikos, Multiscale modelling for cerebrospinal fluid dynamics: multi-compartmental poroelacticity and the role of AQP4, 2014 Spring World Congress on Engineering and Technology, Shanghai, China, 2014/04.

[09] J. C. Vardakis, B. J. Tully, D. Chou and Y. Ventikos, Surgical applications in endoscopic ventriculostomy and aqueductoplasty using multi-compartmental poroelasticity, 1st UK National Conference on Patient-Specific Modeling & Translational Research, Cardiff, Wales, UK, 2013/01.

[08] C. Wang, D. Chou and Y. Ventikos, Microfluidics in curved channels for particle separation, NanoBio Tech-Montreux, Geneva, Switzerland, 2012/11.

[07] Y. C. Chuang, D. Chou, Y. J. Chou and K. C. Chen, Development and application of computation platform for solid-liquid flows, 36th National Conference on Theoretical and Applied Mechanics, Taoyuan, Taiwan, 2012/11.

[06] J. Vardakis, B. Tully, D. Chou and Y. Ventikos, Multi-compartmental poroelastic modelling for CSF production & circulation, 6th European Postgraduate Fluid Dynamics, London, UK, 2012/07.

[05] J. Vardakis, B. Tully, D. Chou and Y. Ventikos, Multi-compartmental poroelasticity for brain modelling, Bioengineering, Oxford, UK, 2012/07.

[04] Y. C. Shu, W. L. Hwang and D. Chou, Message passing using the cover text as secret key, IEEE International Symposium on Biometrics and Security, Taipei, Taiwan, 2012/03.

[03] D. Chou, M. J. Chern, C. Y. Hsieh, C. M. Hsieh and C. P. Chen, Multiscale modeling of DNA stretching in uniform flow, 3rd International Symposium on Computational Mechanics, Taipei, Taiwan, 2011/12.

[02] C. M. Hsieh, W. C. Yang, Robert R. Hwang and D. Chou, Simulation of internal solitary wave generation and evolution in a two-layer fluid system using RANS, 18th National Computational Fluid Dynamic Conference, Taipei, Taiwan, 2011/08.

[01] C. M. Hsieh, T. W. Hsu, D. C. Lo, D. Chou and C. M. Lee, An embedding approach for a traveling wave train over bar/step-type beach profile, Chinese-German Joint Symposium on Hydraulic and Ocean Engineering, Tianjin, China, 2010/09.

Book & Chapters

[01] R.Y. Youh, P.Y. Chen, Y.C. Chao, D.H. Luo, H.H. Chang, Y.L. Chang, W.M. Liu, D. Chou (2020, Oct), Ch09: Biomarkers and Applications in Alzheimer’s Disease, Advances in Biosensing Technology for Medical Diagnosis, Bentham Books

Patents

[01] J. Y. Huang and D. Chou, System, wearable apparatus, method, computer-readable medium and program product for generating and processing emergency alert automatically No. 105110412, TW.

Theses

[03] D. Chou, Computational modelling of brain transport phenomena: application of multicompartmental poroelasticity, University of Oxford, D.Phil. Dissertation, 2017/03.

[02] D. Chou, Multiscale modeling of DNA stretching, University of Alabama in Huntsville, Master Thesis, 2010/12.

[01] D. Chou, An innovation of 3D non-singular boundary integral equations, National Taiwan University, Master Thesis, 2005/06.