周鼎贏博士簡介

下半場開球後,任何事都有可能發生。    —   周鼎贏

          周鼎贏博士於中華民國一百零六年三月取得英國牛津大學工程科學暨生物醫學工程所博士, 而他的博士論文研究課題是針對大腦環境利用多孔彈性力學理論,提出專門描述大腦環境的數學模型,即為一種多重網絡之大腦多孔力學(Cerebroporomechanics), 此模型能夠應用於多尺度神經血管複雜性問題。而其研究目標為建立一個含有最新發現的膠淋巴系統(Glymphatic System)和水通道蛋白(Aquaporins, AQPs) 影響的大腦多孔力學模型,基於此模型來觀察並研究腦神經相關疾病,如阿茲海默症(Alzheimer's Disease ,AD)、腦水腫(Cerebral Oedema)、水腦(Hydrocephalus)及 創傷性腦損傷(Traumatic Brain Injury, TBI)等。
          在其攻讀博士期間,歐盟委員會第七期科研架構(The seventh Framework Programmes, FP7)中的虛 擬人失智症研究計畫(the Virtual Physiological Human: DementiA Research Enabled by IT, VPH-DARE@IT)為其提供資助,以完成該博士學位。 此外,其於中華民國九十八年獲得美國阿拉巴馬大學亨茲維爾分校化工及材料工程系之全額獎學金,且於隔年獲得該校碩士學位。於此期間, 周博士之研究課題為DNA於流場中的摺疊及拉伸力學行為之流固耦合問題(Fluid-structure Interaction Problem, FSI),此研究平台是基於他在 ESI集團下的CFD-ACE+套裝軟體公司工作機會,進而利用他當時維護及開發的Marco-particle模組進行該模擬研究。接著,周博士在中華民國九十四年 取得國立台灣大學工程科學及海洋工程系碩士學位,而其第一篇碩士論文是使用無奇異性邊界積分式(Nonsingular Boundary Integral Equations, BIEs) 解決內流場問題。最後,他在中華民國九十一年取得國立台灣海洋大學系統工程暨造船系學士學位。

專長

  •    多孔力學
  •    傳輸現象
  •    機器學習
  •    影像處理
  •    生醫感測器
  •    計算流體力學


成果發表

期刊論文 (*, equal contribution)

[08] L.W. Guo, J.C. Vardakis, D. Chou, Y. Ventikos (2020, Feb). A multiple-network poroelastic model for biological systems and application to subject-specific modelling of cerebral fluid transport. International Journal of Engineering Science, (IF: 9.219, 01/91, Engineering, Multidisciplinary).

[07] Vardakis I, Guo L, Peach T, Lassila T, Mitolo M, D. Chou, Taylor Z, Varma S, Venneri A, Frangi A, Ventikos Y (2019, Nov). Fluid–structure interaction for highly complex, statistically defined, biological media: Homogenisation and a 3D multi-compartmental poroelastic model for brain biomechanics. Journal of Fluids and Structures, (IF: 2.840, 22/134, Mechanics).

[06] L.W. Guo, J.C. Vardakis, T. Lassila, M. Mitolo, N. Ravikumar, D. Chou, M. Lange, A. Sarrami-Foroushani, B.J. Tully, Z.A. Taylor, S. Varma, A. Venneri, A.F. Frangi, Y. Ventikos (2018, Feb). Subject-specific multiporoelastic model for exploring the risk factors associated with the early stages of Alzheimers disease. Interface Focus, 6; 8(1): 20170019, (IF: 3.514, 21/93, Biology).

[05] P. H. Tsui, J. Fang, K. J. Chang, W. H. Kuo, H. Y. Ma and D. Chou (2017, Jan). Small-window parametric imaging based on information entropy for ultrasound tissue characterization. Scientific Reports, 7, Article No: 41004. (IF: 4.122, 12/64, Multidisciplinary Sciences).

[04] D. Chou, J. C. Vardakis, L. W. Guo, B. J. Tully and Y. Ventikos (2016, Jul). A fully dynamic multicompartmental poroelastic system: application to aqueductal stenosis. Journal of Biomechanics, 49(11), 2306~2312. (IF: 2.664, 25/77, Engineering, Biomedical).

[03] J. C. Vardakis, D. Chou, B. J. Tully, C. C. Hung, T. H. Lee, P. H. Tsui and Y. Ventikos (2016, Jan). Investigating cerebral oedema using poroelasticity. Medical Engineering & Physics, 38(1), 48~57. (IF: 1.819, 46/77, Engineering, Biomedical).

[02] S. B. Huang, D. Chou, Y. H. Chang, K. C. Li, T. K. Chiu, Y. Ventikos and M. H. Wu (2015, Dec). Development of a pneumatically driven active cover lid for multi-well microplates for use in perfusion three-dimensional cell culture. Scientific Reports, 5, Article No: 18352. (IF: 5.228, 07/63, Multidisciplinary Sciences).

[01] D. Chou, J. C. Vardakis and Y. Ventikos, Multiscale modelling for cerebrospinal fluid dynamics: multi-compartmental poroelacticity and the role of AQP4, Journal of Biosciences and Medicines, Volume 2, Pages 1~9, 2014.

研討會論文

[33] B.Z Lu, D. Chou, K. Hsieh, W.J. Liang, C.Y. Yeh, Y.T. Chun, and Y.C. Shu (2019, Jun). Level Set Method for Image Segmentation. 6th International Conference on Computational and Mathematical Biomedical Engineering.

[32] D. Chou, S.K. Liao, J.C. Vardakis, and Y.C. Shu (2019, Jun). An Analytical Steady-state Solution for Cerebral Tissue based on Multiple-network Poroelasticity. 6th International Conference on Computational and Mathematical Biomedical Engineering, Sendai, Japan.

[31] D. Chou, J.C. Vardakis, Y. Ventikos (2018, Jul). A novel poroelastic model of the neuro-glio-vascular unit. 8th World Congress of Biomechanics, Dublin, Ireland.

[30] J.C. Vardakis, L.W. Guo, T. Lassila, M. Mitolo, N. Ravikumar, D. Chou, M. Lange, A.S. Foroushani, B. Tully, Z. Taylor, S. Varma, A. Venneri, A.F. Frangi, Y. Ventikos (2018, Jul). A personalised multi-poroelastic model for exploring the risk factors associated with the early stages of Alzheimer’s disease. 8th World Congress of Biomechanics, Dublin, Ireland.

[29] L.W. Guo, J.C. Vardakis, D. Chou, B. Tully, Yiannis Ventikos (2018, Jul). Subject-specific computational platform of a multiporoelastic model for the simulation of cerebrospinal fluid transport. 8th World Congress of Biomechanics, Dublin, Ireland.

[28] J.C. Vardakis, L.W. Guo, D. Chou, Y. Ventikos (2018, Jun). Using Multicompartmental Poroelasticity to Explore Brain Biomechanics and Cerebral Diseases. IUTAM Symposium on Critical flow dynamics involving moving/deformable structures with design applications, Santorini, Greece.

[27] J.C. Vardakis, L.W. Guo, D. Chou, Y. Ventikos (2018, Jun). Cerebroventricular Fluid Complexity in the early stages of Alzheimer's Disease. 6th European Conference on Computational Mechanics, 7th European Conference on Computational Fluid Dynamics, Glasgow, UK.

[26] J. C. Vardakis, L. W. Guo, D. Chou, B. Tully, G. F. Vindedal, V. Jensen, A. E. Thoren, K. H. Pettersen, S. W. Omholt, O. P. Ottersen, E. A. Nagelhus and Y. Ventikos, Poroelastic modelling of CSF circulation via the incorporation of experimentally derived microscale water transport properties, 5th International Conference on Computational and Mathematical Biomedical Engineering, At University of Pittsburgh, Pittsburgh, PA, United States, 2017/04.

[25] L. W. Guo, J. C. Vardakis, T. Lassila, M. Mitolo, N. Ravikumar, D. Chou, M. Lange, A. S. Foroushani, B. Tully, Z. Taylor, S. Varma, A. Venneri, A. F. Frangi, Y. Ventikos, Investigating dementia via a multi-compartmental poroelastic model of parenchymal tissue, 5th International Conference on Computational and Mathematical Biomedical Engineering, At University of Pittsburgh, Pittsburgh, PA, United States, 2017/04.

[24] Y. Ventikos, J. C. Vardakis, L. W. Guo, T. Lassila, D. Chou, B. Tully, N. Ravikumar, M. Mitolo, M. Lange, A. S. Foroushani, Z. Taylor, S. Varma, A. Venneri and A. F. Frangi, Mechanistic model-based biomarkers, European Congress of Radiology, At Vienna, Austria, 2017/03.

[23] C. W. Chang, H. Y. Chih, D. Chou, Y. C. Shu and K. T. Chuang, Relief of spatiotemporal accessibility overloading with optimal resource placement, Proc. of the IEEE International Conference on Data Mining (triple-blind review, regular paper, acceptance rate=8.5% out of 923 submissions, 2016/09.

[22] J. C. Vardakis, L. W. Guo, D. Chou, B. Tully, T. Lassila, N. Ravikumar, Z. A. Taylor, S. Varma, A. Venneri, A. F. Frangi and Y. Ventikos, Investigating patient-specific cerebroventricular fluid complexity in dementia, Virtual Physiological Human Conference, Amsterdam, Netherlands, 2016/09.

[21] L. W. Guo, J. C. Vardakis, D. Chou, B. Tully, T. Lassila, N. Ravikumar, Z. A. Taylor, S. Varma, A. Venneri, A. F. Frangi and Y. Ventikos, Patient-specific multiporoelastic brain modelling, Virtual Physiological Human Conference, Amsterdam, Netherlands, 2016/09.

[20] L. W. Guo, J. C. Vardakis, D. Chou and Y. Ventikos, Development of a three-dimensional multi-compartmental poroelastic model for the simulation of cerebrospinal fluid transport, 12th World Congress on Computational Mechanics and 6th Asia-Pacific Congress on Computational Mechanics, Seoul, Korea, 2016/07.

[19] J. C. Vardakis, L. W. Guo, D. Chou and Y. Ventikos, Exploring obstructive hydrocephalus through a multiscale modelling approach, 4th International Conference on Computational and Mathematical Biomedical Engineering, Paris, France, 2016/06.

[18] Y. Ventikos, J. C. Vardakis, D. Chou, L. G. Guo and B. Tully, Fluid transport in the ageing brain: an integrative modelling approach, European Congress of Radiology, At Vienna, Austria, 2016/03.

[17] D. Chou, J. C. Vardakis, L. W. Guo and Y. Ventikos, A Fully dynamic multi-compartmental poroelastic system: application to aqueductal stenosis, First Computational Mechanics Conference in Taiwan, Taipei, Taiwan, 2015/10.

[16] J. C. Vardakis, D. Chou, L. W. Guo and Y. Ventikos, Multi-compartmental poroelasticity for the integrative modelling of periventricular lucency, 4th International Conference on Computational and Mathematical Biomedical Engineering, Paris, France, 2015/07.

[15] J. C. Vardakis, D. Chou, L. W. Guo, B. Tully and Y. Ventikos, Investigating cerebral oedema using poroelasticity, 3rd International CSF Dynamics Symposium, Amiens, France, 2015/07.

[14] J. C. Vardakis, D. Chou, B. J. Tully and Y. Ventikos, Multi-compartmental poroelasticity for the integrative modelling of fluid transport in the brain, 9th European Solid Mechanics Conference, Madrid, Spain, 2015/07.

[13] D. Chou, J. C. Vardakis, B. J. Tully and Y. Ventikos, Understanding hydrocephalus using a multi-compartmental poroelasticity model, 18th International Conference on Finite Elements in Flow Problems (FEF2015), Taipei, Taiwan, 2015/03.

[12] J. C. Vardakis, D. Chou, B. J. Tully and Y. Ventikos, A CFD and FEM approach to a multi-compartmental poroelastic model for CSF production and circulation with applications in hydrocephalus treatment and cerebral oedema, 4th Micro and Nano Flows Conference 2014, London, UK, 2014/09.

[11] J. C. Vardakis, D. Chou, B. J. Tully and Y. Ventikos, Exploring a multi-compartmental poroelastic model for the integrative modelling of fluid transport, 7th World Congress of Biomechanics, Boston, USA, 2014/07.

[10] D. Chou, J. C. Vardakis and Y. Ventikos, Multiscale modelling for cerebrospinal fluid dynamics: multi-compartmental poroelacticity and the role of AQP4, 2014 Spring World Congress on Engineering and Technology, Shanghai, China, 2014/04.

[09] J. C. Vardakis, B. J. Tully, D. Chou and Y. Ventikos, Surgical applications in endoscopic ventriculostomy and aqueductoplasty using multi-compartmental poroelasticity, 1st UK National Conference on Patient-Specific Modeling & Translational Research, Cardiff, Wales, UK, 2013/01.

[08] C. Wang, D. Chou and Y. Ventikos, Microfluidics in curved channels for particle separation, NanoBio Tech-Montreux, Geneva, Switzerland, 2012/11.

[07] Y. C. Chuang, D. Chou, Y. J. Chou and K. C. Chen, Development and application of computation platform for solid-liquid flows, 36th National Conference on Theoretical and Applied Mechanics, Taoyuan, Taiwan, 2012/11.

[06] J. Vardakis, B. Tully, D. Chou and Y. Ventikos, Multi-compartmental poroelastic modelling for CSF production & circulation, 6th European Postgraduate Fluid Dynamics, London, UK, 2012/07.

[05] J. Vardakis, B. Tully, D. Chou and Y. Ventikos, Multi-compartmental poroelasticity for brain modelling, Bioengineering, Oxford, UK, 2012/07.

[04] Y. C. Shu, W. L. Hwang and D. Chou, Message passing using the cover text as secret key, IEEE International Symposium on Biometrics and Security, Taipei, Taiwan, 2012/03.

[03] D. Chou, M. J. Chern, C. Y. Hsieh, C. M. Hsieh and C. P. Chen, Multiscale modeling of DNA stretching in uniform flow, 3rd International Symposium on Computational Mechanics, Taipei, Taiwan, 2011/12.

[02] C. M. Hsieh, W. C. Yang, Robert R. Hwang and D. Chou, Simulation of internal solitary wave generation and evolution in a two-layer fluid system using RANS, 18th National Computational Fluid Dynamic Conference, Taipei, Taiwan, 2011/08.

[01] C. M. Hsieh, T. W. Hsu, D. C. Lo, D. Chou and C. M. Lee, An embedding approach for a traveling wave train over bar/step-type beach profile, Chinese-German Joint Symposium on Hydraulic and Ocean Engineering, Tianjin, China, 2010/09.

專書與章節

[01] R.Y. Youh, P.Y. Chen, Y.C. Chao, D.H. Luo, H.H. Chang, Y.L. Chang, W.M. Liu, D. Chou (2020, Oct), Ch09: Biomarkers and Applications in Alzheimer’s Disease, Advances in Biosensing Technology for Medical Diagnosis, Bentham Books

專利

[01] 黃靖元、周鼎贏, ”自動緊急求救系統、穿戴式裝置、訊號產生與處理方法、電腦可讀取媒體及電腦程式產品”, 105110412, 台灣

學位論文

[03] D. Chou, Computational modelling of brain transport phenomena: application of multicompartmental poroelasticity, University of Oxford, D.Phil. Dissertation, 2017/03.

[02] D. Chou, Multiscale modeling of DNA stretching, University of Alabama in Huntsville, Master Thesis, 2010/12.

[01] D. Chou, An innovation of 3D non-singular boundary integral equations, National Taiwan University, Master Thesis, 2005/06.